How antibodies act as natural adjuvants
A Getahun, B Heyman - Immunology letters, 2006 - Elsevier
Antibodies can act like adjuvants. They can potently enhance the antibody response, and in
the case of IgG and IgE also the T cell response, to the very antigen they are specific for. In
this review we will discuss the recent advances made in our understanding of the underlying
mechanisms of antibody-mediated feedback enhancement. The immuno-stimulatory
properties of IgM, IgG1, IgG2a, IgG2b, IgG3 and IgE will be reviewed in relationship to the
complement system and Fc receptors and the physiological relevance will be discussed.
the case of IgG and IgE also the T cell response, to the very antigen they are specific for. In
this review we will discuss the recent advances made in our understanding of the underlying
mechanisms of antibody-mediated feedback enhancement. The immuno-stimulatory
properties of IgM, IgG1, IgG2a, IgG2b, IgG3 and IgE will be reviewed in relationship to the
complement system and Fc receptors and the physiological relevance will be discussed.