Mitochondrial dynamics and their potential as a therapeutic target
BN Whitley, EA Engelhart, S Hoppins - Mitochondrion, 2019 - Elsevier
Mitochondrial dynamics shape the mitochondrial network and contribute to mitochondrial
function and quality control. Mitochondrial fusion and division are integrated into diverse
cellular functions and respond to changes in cell physiology. Imbalanced mitochondrial
dynamics are associated with a range of diseases that are broadly characterized by
impaired mitochondrial function and increased cell death. In various disease models,
modulating mitochondrial fusion and division with either small molecules or genetic …
function and quality control. Mitochondrial fusion and division are integrated into diverse
cellular functions and respond to changes in cell physiology. Imbalanced mitochondrial
dynamics are associated with a range of diseases that are broadly characterized by
impaired mitochondrial function and increased cell death. In various disease models,
modulating mitochondrial fusion and division with either small molecules or genetic …