[HTML][HTML] Poly (ADP-ribose) polymerase inhibitors sensitize cancer cells to death receptor-mediated apoptosis by enhancing death receptor expression
XW Meng, BD Koh, JS Zhang, KS Flatten… - Journal of Biological …, 2014 - ASBMB
Recombinant human tumor necrosis factor-α-related apoptosis inducing ligand (TRAIL),
agonistic monoclonal antibodies to TRAIL receptors, and small molecule TRAIL receptor
agonists are in various stages of preclinical and early phase clinical testing as potential
anticancer drugs. Accordingly, there is substantial interest in understanding factors that
affect sensitivity to these agents. In the present study we observed that the poly (ADP-ribose)
polymerase (PARP) inhibitors olaparib and veliparib sensitize the myeloid leukemia cell …
agonistic monoclonal antibodies to TRAIL receptors, and small molecule TRAIL receptor
agonists are in various stages of preclinical and early phase clinical testing as potential
anticancer drugs. Accordingly, there is substantial interest in understanding factors that
affect sensitivity to these agents. In the present study we observed that the poly (ADP-ribose)
polymerase (PARP) inhibitors olaparib and veliparib sensitize the myeloid leukemia cell …