Successful treatment with tocainide of recessive generalized congenital myotonia
EW Streib - Annals of Neurology: Official Journal of the …, 1986 - Wiley Online Library
EW Streib
Annals of Neurology: Official Journal of the American Neurological …, 1986•Wiley Online LibraryA patient with recessive generalized congenital myotonia and severe, disabling weakness
underwent various forms of treatment while being monitored electrophysiologically.
Phenytoin, verapamil, and acetazolamide were ineffective, but tocainide yielded good
results. Improvement was dose‐dependent, and was limited by irritability and action tremor
when the patient was taking 1,600 mg per day.
underwent various forms of treatment while being monitored electrophysiologically.
Phenytoin, verapamil, and acetazolamide were ineffective, but tocainide yielded good
results. Improvement was dose‐dependent, and was limited by irritability and action tremor
when the patient was taking 1,600 mg per day.
Abstract
A patient with recessive generalized congenital myotonia and severe, disabling weakness underwent various forms of treatment while being monitored electrophysiologically. Phenytoin, verapamil, and acetazolamide were ineffective, but tocainide yielded good results. Improvement was dose‐dependent, and was limited by irritability and action tremor when the patient was taking 1,600 mg per day.
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