Suppressors of cytokine signaling (SOCS) in T cell differentiation, maturation, and function
DC Palmer, NP Restifo - Trends in immunology, 2009 - cell.com
DC Palmer, NP Restifo
Trends in immunology, 2009•cell.comCytokines are key modulators of T cell biology, but their influence can be attenuated by
suppressors of cytokine signaling (SOCS), a family of proteins consisting of eight members,
SOCS1-7 and CIS. SOCS proteins regulate cytokine signals that control the polarization of
CD4+ T cells into Th1, Th2, Th17, and T regulatory cell lineages, the maturation of CD8+ T
cells from naïve to" stem-cell memory"(Tscm), central memory (Tcm), and effector memory
(Tem) states, and the activation of these lymphocytes. Understanding how SOCS family …
suppressors of cytokine signaling (SOCS), a family of proteins consisting of eight members,
SOCS1-7 and CIS. SOCS proteins regulate cytokine signals that control the polarization of
CD4+ T cells into Th1, Th2, Th17, and T regulatory cell lineages, the maturation of CD8+ T
cells from naïve to" stem-cell memory"(Tscm), central memory (Tcm), and effector memory
(Tem) states, and the activation of these lymphocytes. Understanding how SOCS family …
Cytokines are key modulators of T cell biology, but their influence can be attenuated by suppressors of cytokine signaling (SOCS), a family of proteins consisting of eight members, SOCS1-7 and CIS. SOCS proteins regulate cytokine signals that control the polarization of CD4+ T cells into Th1, Th2, Th17, and T regulatory cell lineages, the maturation of CD8+ T cells from naïve to "stem-cell memory" (Tscm), central memory (Tcm), and effector memory (Tem) states, and the activation of these lymphocytes. Understanding how SOCS family members regulate T cell maturation, differentiation, and function might prove critical in improving adoptive immunotherapy for cancer and therapies aimed at treating autoimmune and infectious diseases.
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