[HTML][HTML] Repeat-associated non-AUG (RAN) translation: insights from pathology
M Banez-Coronel, LPW Ranum - Laboratory Investigation, 2019 - Elsevier
More than 40 different neurological diseases are caused by microsatellite repeat
expansions. Since the discovery of repeat-associated non-AUG (RAN) translation by Zu et
al. in 2011, nine expansion disorders have been identified as RAN-positive diseases. RAN
proteins are translated from different types of nucleotide repeat expansions and can be
produced from both sense and antisense transcripts. In some diseases, RAN proteins have
been shown to accumulate in affected brain regions. Here we review the pathological and …
expansions. Since the discovery of repeat-associated non-AUG (RAN) translation by Zu et
al. in 2011, nine expansion disorders have been identified as RAN-positive diseases. RAN
proteins are translated from different types of nucleotide repeat expansions and can be
produced from both sense and antisense transcripts. In some diseases, RAN proteins have
been shown to accumulate in affected brain regions. Here we review the pathological and …