Coagulation factor XIII (FXIII) is a transglutaminase with a well defined role in the final stages
of blood coagulation. Active FXIII (FXIIIa) catalyzes the formation of ϵ-(γ-glutamyl) lysine
isopeptide bonds between specific Gln and Lys residues. The primary physiological
outcome of this catalytic activity is stabilization of the fibrin clot during coagulation. The
stabilization is achieved through the introduction of cross-links between fibrin monomers
and through cross-linking of proteins with anti-fibrinolytic activity to fibrin. FXIIIa additionally …