Factor XIII (FXIII) is a multifunctional pro-γ-transglutaminase that, in addition to its well-
known role in hemostasis, has a crucial role in angiogenesis, maintenance of pregnancy,
wound healing, bone metabolism, and even cardio protection. FXIII deficiency (FXIIID) is a
rare bleeding disorder (RBD) with an estimated incidence of one per two million that is
accompanied by life-threatening bleeding such as umbilical cord bleeding, recurrent
spontaneous miscarriage, and intracranial hemorrhage (ICH). Today, the disease is …