Mast cell chymase decreases the severity of group B Streptococcus infections

C Gendrin, NJ Shubin, E Boldenow, S Merillat… - Journal of Allergy and …, 2018 - Elsevier
Background Group B Streptococcus (GBS) or Streptococcus agalactiae are β-hemolytic
gram-positive bacteria that colonize the lower genital tracts of women and are frequently
associated with infections during pregnancy. Innate immune defenses are critical for
controlling GBS dissemination and systemic infection. Mast cells are resident sentinel cells
that come into contact with pathogens early during colonization and infection. Objective We
aimed to investigate the contribution of chymase to systemic GBS infection and rates of …