[HTML][HTML] Functional inactivation of pulmonary MAIT cells following 5-OP-RU treatment of non-human primates
S Sakai, NE Lora, KD Kauffman, DE Dorosky, S Oh… - Mucosal …, 2021 - Elsevier
Targeting MAIT cells holds promise for the treatment of different diseases and infections. We
previously showed that treatment of Mycobacterium tuberculosis infected mice with 5-OP-
RU, a major antigen for MAIT cells, expands MAIT cells and enhances bacterial control.
Here we treated M. tuberculosis infected rhesus macaques with 5-OP-RU intratracheally but
found no clinical or microbiological benefit. In fact, after 5-OP-RU treatment MAIT cells did
not expand, but rather upregulated PD-1 and lost the ability to produce multiple cytokines, a …
previously showed that treatment of Mycobacterium tuberculosis infected mice with 5-OP-
RU, a major antigen for MAIT cells, expands MAIT cells and enhances bacterial control.
Here we treated M. tuberculosis infected rhesus macaques with 5-OP-RU intratracheally but
found no clinical or microbiological benefit. In fact, after 5-OP-RU treatment MAIT cells did
not expand, but rather upregulated PD-1 and lost the ability to produce multiple cytokines, a …
