The role of COX-2 in angiogenesis and rheumatoid arthritis☆
JM Woods, A Mogollon, MA Amin, RJ Martinez… - … and molecular pathology, 2003 - Elsevier
Recent evidence suggests that cyclooxygenase (COX)-2 is a mediator of angiogenesis, and
COX-2 activity is known to be upregulated in the rheumatoid arthritis (RA) synovium. We
examined whether mediation of angiogenesis by COX-2 was occuring in cells of the RA
synovium and in microvascular endothelial cells (ECs) that are similar to those found in the
RA synovium. We demonstrate that rofecoxib, a selective COX-2 inhibitor, acts directly on
human dermal microvascular ECs (HMVECs) to inhibit their chemotactic and tube forming …
COX-2 activity is known to be upregulated in the rheumatoid arthritis (RA) synovium. We
examined whether mediation of angiogenesis by COX-2 was occuring in cells of the RA
synovium and in microvascular endothelial cells (ECs) that are similar to those found in the
RA synovium. We demonstrate that rofecoxib, a selective COX-2 inhibitor, acts directly on
human dermal microvascular ECs (HMVECs) to inhibit their chemotactic and tube forming …