Spontaneous neutrophil apoptosis involves caspase 3-mediated activation of protein kinase C-δ
Neutrophils are short-lived leukocytes that die by apoptosis. Whereas stress-induced
apoptosis is mediated by the p38 mitogen-activated protein (MAP) kinase pathway (Frasch,
SC, Nick, JA, Fadok, VA, Bratton, DL, Worthen, GS, and Henson, PM (1998) J. Biol. Chem.
273, 8389–8397), signals regulating spontaneous neutrophil apoptosis have not been fully
determined. In this study we found increased activation of protein kinase C (PKC)-β and-δ in
neutrophils undergoing spontaneous apoptosis, but we show that only activation of PKC-δ …
apoptosis is mediated by the p38 mitogen-activated protein (MAP) kinase pathway (Frasch,
SC, Nick, JA, Fadok, VA, Bratton, DL, Worthen, GS, and Henson, PM (1998) J. Biol. Chem.
273, 8389–8397), signals regulating spontaneous neutrophil apoptosis have not been fully
determined. In this study we found increased activation of protein kinase C (PKC)-β and-δ in
neutrophils undergoing spontaneous apoptosis, but we show that only activation of PKC-δ …
