Effects of aerosolized adenosine 5′-triphosphate in smokers and patients with COPD
OK Basoglu, PJ Barnes, SA Kharitonov, A Pelleg - Chest, 2015 - Elsevier
BACKGROUND Extracellular adenosine 5′-triphosphate (ATP) stimulates vagal C and Ad
fibers in the lung, resulting in pronounced bronchoconstriction and cough mediated by
P2X2/3 receptors located on vagal sensory nerve terminals. We investigated the effects of
nebulized ATP on cough and symptoms in control subjects, healthy smokers, and patients
with COPD and compared these responses to the effects of inhaled adenosine, the
metabolite of ATP. METHODS We studied the effects of inhaled ATP and adenosine …
fibers in the lung, resulting in pronounced bronchoconstriction and cough mediated by
P2X2/3 receptors located on vagal sensory nerve terminals. We investigated the effects of
nebulized ATP on cough and symptoms in control subjects, healthy smokers, and patients
with COPD and compared these responses to the effects of inhaled adenosine, the
metabolite of ATP. METHODS We studied the effects of inhaled ATP and adenosine …