Increased extracellular levels of the novel proinflammatory cytokine high mobility group box chromosomal protein 1 in minor salivary glands of patients with Sjögren's …
M Ek, K Popovic, H Erlandsson Harris… - … : Official Journal of …, 2006 - Wiley Online Library
Arthritis & Rheumatism: Official Journal of the American College …, 2006•Wiley Online Library
Objective. To investigate the expression of the novel proinflammatory cytokine high mobility
group box chromosomal protein 1 (HMGB-1) in the salivary glands of patients with Sjögren's
syndrome (SS) and patients with sicca symptoms. Methods. Biopsy samples from the minor
labial salivary glands of patients with SS, patients with sicca symptoms but no diagnosis of
SS, and healthy controls were investigated. Expression of HMGB-1, tumor necrosis factor
(TNF), and interleukin-1ß (IL-1ß) was analyzed using immunohistochemical staining on …
group box chromosomal protein 1 (HMGB-1) in the salivary glands of patients with Sjögren's
syndrome (SS) and patients with sicca symptoms. Methods. Biopsy samples from the minor
labial salivary glands of patients with SS, patients with sicca symptoms but no diagnosis of
SS, and healthy controls were investigated. Expression of HMGB-1, tumor necrosis factor
(TNF), and interleukin-1ß (IL-1ß) was analyzed using immunohistochemical staining on …
Objective. To investigate the expression of the novel proinflammatory cytokine high mobility group box chromosomal protein 1 (HMGB-1) in the salivary glands of patients with Sjögren’s syndrome (SS) and patients with sicca symptoms.
Methods. Biopsy samples from the minor labial salivary glands of patients with SS, patients with sicca symptoms but no diagnosis of SS, and healthy controls were investigated. Expression of HMGB-1, tumor necrosis factor (TNF), and interleukin-1ß (IL-1ß) was analyzed using immunohistochemical staining on consecutive cryosections.
Results. Increased expression of HMGB-1 was observed among the large infiltrates of mononuclear cells found in biopsy samples from patients with SS, and the degree of extracellular HMGB-1 was significantly higher in patients with SS compared with patients with sicca symptoms and with healthy controls (P< 0.05 and
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