[HTML][HTML] Targeting androgen signaling in ILC2s protects from IL-33–driven lung inflammation, independently of KLRG1
E Blanquart, A Mandonnet, M Mars, C Cenac… - Journal of Allergy and …, 2022 - Elsevier
Background Allergic asthma is more severe and frequent in women than in men. In male
mice, androgens negatively control group 2 innate lymphoid cell (ILC2) development and
function by yet unknown mechanisms. Objectives We sought to investigate the impact of
androgen on ILC2 homeostasis and IL-33–mediated inflammation in female lungs. We
evaluated the role of androgen receptor (AR) signaling and the contribution of the putative
inhibitory receptor killer cell lectin-like receptor G1 (KLRG1). Methods Subcutaneous pellets …
mice, androgens negatively control group 2 innate lymphoid cell (ILC2) development and
function by yet unknown mechanisms. Objectives We sought to investigate the impact of
androgen on ILC2 homeostasis and IL-33–mediated inflammation in female lungs. We
evaluated the role of androgen receptor (AR) signaling and the contribution of the putative
inhibitory receptor killer cell lectin-like receptor G1 (KLRG1). Methods Subcutaneous pellets …