Dynamic role of epithelium-derived cytokines in asthma
KR Bartemes, H Kita - Clinical immunology, 2012 - Elsevier
Asthma is an inflammatory disorder of the airways, characterized by infiltration of mast cells,
eosinophils, and Th2-type CD4+ T cells in the airway wall. Airway epithelium constitutes the
first line of interaction with our atmospheric environment. The protective barrier function of
the airway epithelium is likely impaired in asthma. Furthermore, recent studies suggest
critical immunogenic and immunomodulatory functions of airway epithelium. In particular, a
triad of cytokines, including IL-25, IL-33 and TSLP, is produced and released by airway …
eosinophils, and Th2-type CD4+ T cells in the airway wall. Airway epithelium constitutes the
first line of interaction with our atmospheric environment. The protective barrier function of
the airway epithelium is likely impaired in asthma. Furthermore, recent studies suggest
critical immunogenic and immunomodulatory functions of airway epithelium. In particular, a
triad of cytokines, including IL-25, IL-33 and TSLP, is produced and released by airway …