Small molecule compounds that induce cellular senescence

NV Petrova, AK Velichko, SV Razin, OL Kantidze - Aging Cell, 2016 - Wiley Online Library
Aging Cell, 2016Wiley Online Library
To date, dozens of stress‐induced cellular senescence phenotypes have been reported.
These cellular senescence states may differ substantially from each other, as well as from
replicative senescence through the presence of specific senescence features. Here, we
attempted to catalog virtually all of the cellular senescence‐like states that can be induced
by low molecular weight compounds. We summarized biological markers, molecular
pathways involved in senescence establishment, and specific traits of cellular senescence …
Summary
To date, dozens of stress‐induced cellular senescence phenotypes have been reported. These cellular senescence states may differ substantially from each other, as well as from replicative senescence through the presence of specific senescence features. Here, we attempted to catalog virtually all of the cellular senescence‐like states that can be induced by low molecular weight compounds. We summarized biological markers, molecular pathways involved in senescence establishment, and specific traits of cellular senescence states induced by more than fifty small molecule compounds.
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