15-Lipoxygenase 1 in nasal polyps promotes CCL26/eotaxin 3 expression through extracellular signal-regulated kinase activation
Z Li, M Zeng, Y Deng, J Zhao, X Zhou… - Journal of Allergy and …, 2019 - Elsevier
Background 15-Lipoxygenase 1 (15LO1) is expressed in airway epithelial cells in patients
with type 2–high asthma in association with eosinophilia. Chronic rhinosinusitis with nasal
polyps (CRSwNP) is also associated with type 2 inflammation and eosinophilia.
CCL26/eotaxin 3 has been reported to be regulated by 15LO1 in lower airway epithelial
cells. However, its relation to 15LO1 in patients with CRSwNP or mechanisms for its
activation are unclear. Objective We sought to evaluate 15LO1 and CCL26 expression in …
with type 2–high asthma in association with eosinophilia. Chronic rhinosinusitis with nasal
polyps (CRSwNP) is also associated with type 2 inflammation and eosinophilia.
CCL26/eotaxin 3 has been reported to be regulated by 15LO1 in lower airway epithelial
cells. However, its relation to 15LO1 in patients with CRSwNP or mechanisms for its
activation are unclear. Objective We sought to evaluate 15LO1 and CCL26 expression in …
