Activation of the 15-lipoxygenase pathway in aspirin-exacerbated respiratory disease
WW Stevens, AG Staudacher, KE Hulse… - Journal of Allergy and …, 2021 - Elsevier
Background Aspirin-exacerbated respiratory disease (AERD) is characterized by asthma,
chronic rhinosinusitis with nasal polyps (CRSwNP), and an intolerance of medications that
inhibit cyclooxygenase-1. Patients with AERD have more severe upper and lower
respiratory tract disease than do aspirin-tolerant patients with CRSwNP. A dysregulation in
arachidonic acid metabolism is thought to contribute to the enhanced sinonasal
inflammation in AERD. Objective Our aim was to utilize an unbiased approach investigating …
chronic rhinosinusitis with nasal polyps (CRSwNP), and an intolerance of medications that
inhibit cyclooxygenase-1. Patients with AERD have more severe upper and lower
respiratory tract disease than do aspirin-tolerant patients with CRSwNP. A dysregulation in
arachidonic acid metabolism is thought to contribute to the enhanced sinonasal
inflammation in AERD. Objective Our aim was to utilize an unbiased approach investigating …
