Background Nasal transcriptomics can provide an accessible window into asthma
pathobiology. Objective Our goal was to move beyond gene signatures of asthma to identify
master regulator genes that causally regulate genes associated with asthma phenotypes.
Methods We recruited 156 children with severe persistent asthma and controls for nasal
transcriptome profiling and applied network-based and probabilistic causal methods to
identify severe asthma genes and their master regulators. We then took the same approach …