Connective tissue growth factor (CTGF/CCN2) in hepatic fibrosis
AW Rachfal, DR Brigstock - Hepatology research, 2003 - Elsevier
Connective tissue growth factor (CTGF/CCN2) is a highly profibrogenic molecule which is
overexpressed in many fibrotic lesions, including those of the liver. CTGF/CCN2 is
transcriptionally activated by transforming growth factor-beta (TGF-β) and appears to
mediate some of the extracellular matrix (ECM)-inducing properties that have been
previously attributed to TGF-β. CTGF/CCN2 and TGF-β stimulate connective tissue cell
proliferation and ECM synthesis in vitro and exhibit shared fibrogenic and angiogenic …
overexpressed in many fibrotic lesions, including those of the liver. CTGF/CCN2 is
transcriptionally activated by transforming growth factor-beta (TGF-β) and appears to
mediate some of the extracellular matrix (ECM)-inducing properties that have been
previously attributed to TGF-β. CTGF/CCN2 and TGF-β stimulate connective tissue cell
proliferation and ECM synthesis in vitro and exhibit shared fibrogenic and angiogenic …