[HTML][HTML] CCAAT/enhancer-binding protein α (C/EBPα) is important for osteoclast differentiation and activity
CCAAT/enhancer-binding protein (C/EBPα) can appoint mouse bone marrow (MBM) cells to
the osteoclast (OC) lineage for osteoclastogenesis. However, whether C/EBPα is also
involved in OC differentiation and activity is unknown. Here we demonstrated that C/EBPα
overexpression in MBM cells can promote OC differentiation and strongly induce the
expression of the OC genes encoding the nuclear factor of activated T-cells, c1 (NFATc1),
cathepsin K (Cstk), and tartrate-resistant acid phosphatase 5 (TRAP) with receptor activator …
the osteoclast (OC) lineage for osteoclastogenesis. However, whether C/EBPα is also
involved in OC differentiation and activity is unknown. Here we demonstrated that C/EBPα
overexpression in MBM cells can promote OC differentiation and strongly induce the
expression of the OC genes encoding the nuclear factor of activated T-cells, c1 (NFATc1),
cathepsin K (Cstk), and tartrate-resistant acid phosphatase 5 (TRAP) with receptor activator …