The mTOR pathway is frequently activated in pancreatic ductal adenocarcinoma and chronic pancreatitis
AM Bellizzi, M Bloomston, XP Zhou… - Applied …, 2010 - journals.lww.com
Materials and Methods Tissue microarrays were constructed from 49 PDA, 27 CP, and 12
NL. Cases were scored as follows: PTEN (intact:≥ 5% staining and lost:< 5%) and p-RPS6
(0, 1+: modest intensity in≥ 5% of cells and 2+: strong intensity≥ 5% of cells). Results Forty-
one percent of PDAs demonstrated loss of PTEN, and 75% demonstrated p-RPS6
immunoreactivity (1+ in 22 and 2+ in 3). PTEN was uniformly intact in NL and CP. Although p-
RPS6 immunoreactivity was only noted in 1 NL control (8%), 1+ positivity was observed in …
NL. Cases were scored as follows: PTEN (intact:≥ 5% staining and lost:< 5%) and p-RPS6
(0, 1+: modest intensity in≥ 5% of cells and 2+: strong intensity≥ 5% of cells). Results Forty-
one percent of PDAs demonstrated loss of PTEN, and 75% demonstrated p-RPS6
immunoreactivity (1+ in 22 and 2+ in 3). PTEN was uniformly intact in NL and CP. Although p-
RPS6 immunoreactivity was only noted in 1 NL control (8%), 1+ positivity was observed in …