[HTML][HTML] CD147, CD44, and the epidermal growth factor receptor (EGFR) signaling pathway cooperate to regulate breast epithelial cell invasiveness
GD Grass, LB Tolliver, M Bratoeva, BP Toole - Journal of Biological …, 2013 - ASBMB
The immunoglobulin superfamily glycoprotein CD147 (emmprin; basigin) is associated with
an invasive phenotype in various types of cancers, including malignant breast cancer. We
showed recently that up-regulation of CD147 in non-transformed, non-invasive breast
epithelial cells is sufficient to induce an invasive phenotype characterized by membrane
type-1 matrix metalloproteinase (MT1-MMP)-dependent invadopodia activity (Grass, GD,
Bratoeva, M., and Toole, BP (2012) Regulation of invadopodia formation and activity by …
an invasive phenotype in various types of cancers, including malignant breast cancer. We
showed recently that up-regulation of CD147 in non-transformed, non-invasive breast
epithelial cells is sufficient to induce an invasive phenotype characterized by membrane
type-1 matrix metalloproteinase (MT1-MMP)-dependent invadopodia activity (Grass, GD,
Bratoeva, M., and Toole, BP (2012) Regulation of invadopodia formation and activity by …