Hepatic and serum levels of miR-122 after chronic HCV-induced fibrosis
J Trebicka, E Anadol, N Elfimova, I Strack… - Journal of …, 2013 - Elsevier
BACKGROUND & AIMS: The progression of liver fibrosis in patients with chronic hepatitis C
(CHC) is important to decide on the treatment of the virus. As liver biopsy and liver stiffness
measurement for staging of fibrosis present limitations, circulating levels of miR-122 have
been suggested as a novel biomarker to predict the extent of liver injury. We evaluated the
potential of miR-122 as an indicator of fibrosis progression in CHC infection and performed,
for the first time, a comprehensive analysis of hepatic and circulating miR-122 levels in …
(CHC) is important to decide on the treatment of the virus. As liver biopsy and liver stiffness
measurement for staging of fibrosis present limitations, circulating levels of miR-122 have
been suggested as a novel biomarker to predict the extent of liver injury. We evaluated the
potential of miR-122 as an indicator of fibrosis progression in CHC infection and performed,
for the first time, a comprehensive analysis of hepatic and circulating miR-122 levels in …