KEAP1-NRF2 complex in ischemia-induced hepatocellular damage of mouse liver transplants
Background & Aims The Keap1-Nrf2 signaling pathway regulates host cell defense
responses against oxidative stress and maintains the cellular redox balance. Methods We
investigated the function/molecular mechanisms by which Keap1-Nrf2 complex may
influence liver ischemia/reperfusion injury (IRI) in a mouse model of hepatic cold storage (20
h at 4° C) followed by orthotopic liver transplantation (OLT). Results The Keap1 hepatocyte-
specific knockout (HKO) in the donor liver ameliorated post-transplant IRI, evidenced by …
responses against oxidative stress and maintains the cellular redox balance. Methods We
investigated the function/molecular mechanisms by which Keap1-Nrf2 complex may
influence liver ischemia/reperfusion injury (IRI) in a mouse model of hepatic cold storage (20
h at 4° C) followed by orthotopic liver transplantation (OLT). Results The Keap1 hepatocyte-
specific knockout (HKO) in the donor liver ameliorated post-transplant IRI, evidenced by …