[HTML][HTML] Icosabutate exerts beneficial effects upon insulin sensitivity, hepatic inflammation, lipotoxicity, and fibrosis in mice
AM van den Hoek, EJ Pieterman… - Hepatology …, 2020 - journals.lww.com
Icosabutate is a structurally engineered eicosapentaenoic acid derivative under
development for nonalcoholic steatohepatitis (NASH). In this study, we investigated the
absorption and distribution properties of icosabutate in relation to liver targeting and used
rodents to evaluate the effects of icosabutate on glucose metabolism, insulin resistance, as
well as hepatic steatosis, inflammation, lipotoxicity, and fibrosis. The absorption, tissue
distribution, and excretion of icosabutate was investigated in rats along with its effects in …
development for nonalcoholic steatohepatitis (NASH). In this study, we investigated the
absorption and distribution properties of icosabutate in relation to liver targeting and used
rodents to evaluate the effects of icosabutate on glucose metabolism, insulin resistance, as
well as hepatic steatosis, inflammation, lipotoxicity, and fibrosis. The absorption, tissue
distribution, and excretion of icosabutate was investigated in rats along with its effects in …