[HTML][HTML] Intestine-specific deletion of acyl-CoA: monoacylglycerol acyltransferase (MGAT) 2 protects mice from diet-induced obesity and glucose intolerance
DW Nelson, Y Gao, MI Yen, CLE Yen - Journal of Biological Chemistry, 2014 - ASBMB
The absorption of dietary fat involves the re-esterification of digested triacylglycerol in the
enterocytes, a process catalyzed by acyl-CoA: monoacylglycerol acyltransferase (MGAT) 2.
Mice without a functional gene encoding MGAT2 (Mogat2−/−) are protected from diet-
induced obesity. Surprisingly, these mice absorb normal amounts of dietary fat but increase
their energy expenditure. MGAT2 is expressed in tissues besides intestine, including
adipose tissue in both mice and humans. To test the hypothesis that intestinal MGAT2 …
enterocytes, a process catalyzed by acyl-CoA: monoacylglycerol acyltransferase (MGAT) 2.
Mice without a functional gene encoding MGAT2 (Mogat2−/−) are protected from diet-
induced obesity. Surprisingly, these mice absorb normal amounts of dietary fat but increase
their energy expenditure. MGAT2 is expressed in tissues besides intestine, including
adipose tissue in both mice and humans. To test the hypothesis that intestinal MGAT2 …