[HTML][HTML] Critical role of micelles in pancreatic lipase activation revealed by small angle neutron scattering
D Pignol, L Ayvazian, B Kerfelec, P Timmins… - Journal of Biological …, 2000 - ASBMB
In the duodenum, pancreatic lipase (PL) develops its activity on triglycerides by binding to
the bile-emulsified oil droplets in the presence of its protein cofactor pancreatic colipase
(PC). The neutron crystal structure of a PC-PL-micelle complex (Hermoso, J., Pignol, D.,
Penel, S., Roth, M., Chapus, C., and Fontecilla-Camps, JC (1997) EMBO J. 16, 5531–5536)
has suggested that the stabilization of the enzyme in its active conformation and its
adsorption to the emulsified oil droplets are mediated by a preformed lipase-colipase …
the bile-emulsified oil droplets in the presence of its protein cofactor pancreatic colipase
(PC). The neutron crystal structure of a PC-PL-micelle complex (Hermoso, J., Pignol, D.,
Penel, S., Roth, M., Chapus, C., and Fontecilla-Camps, JC (1997) EMBO J. 16, 5531–5536)
has suggested that the stabilization of the enzyme in its active conformation and its
adsorption to the emulsified oil droplets are mediated by a preformed lipase-colipase …