[HTML][HTML] Genetic deletion of the bacterial sensor NOD2 improves murine Crohn's disease-like ileitis independent of functional dysbiosis
D Corridoni, A Rodriguez-Palacios, G Di Stefano… - Mucosal …, 2017 - Elsevier
Although genetic polymorphisms in NOD2 (nucleotide-binding oligomerization domain-
containing 2) have been associated with the pathogenesis of Crohn's disease (CD), little is
known regarding the role of wild-type (WT) NOD2 in the gut. To date, most murine studies
addressing the role of WT Nod2 have been conducted using healthy (ileitis/colitis-free)
mouse strains. Here, we evaluated the effects of Nod2 deletion in a murine model of
spontaneous ileitis, ie, the SAMP1Yit/Fc (SAMP) strain, which closely resembles CD …
containing 2) have been associated with the pathogenesis of Crohn's disease (CD), little is
known regarding the role of wild-type (WT) NOD2 in the gut. To date, most murine studies
addressing the role of WT Nod2 have been conducted using healthy (ileitis/colitis-free)
mouse strains. Here, we evaluated the effects of Nod2 deletion in a murine model of
spontaneous ileitis, ie, the SAMP1Yit/Fc (SAMP) strain, which closely resembles CD …