[HTML][HTML] Regulation of apoA-I gene expression: mechanism of action of estrogen and genistein
S Lamon-Fava, D Micherone - Journal of lipid research, 2004 - ASBMB
We have previously shown that 17-β-estradiol (E 2) and genistein increase the expression of
apolipoprotein AI (apoA-I), the major protein component of HDL, in Hep G2 cells. To
elucidate the mechanism mediating the increase in apoA-I gene expression by these
compounds, plasmid constructs containing serial deletions of the apoA-I promoter region
were generated. The smallest region maintaining response to E 2 and genistein spanned
the− 220 to− 148 sequence, and the estrogen antagonist ICI182, 780 completely inhibited …
apolipoprotein AI (apoA-I), the major protein component of HDL, in Hep G2 cells. To
elucidate the mechanism mediating the increase in apoA-I gene expression by these
compounds, plasmid constructs containing serial deletions of the apoA-I promoter region
were generated. The smallest region maintaining response to E 2 and genistein spanned
the− 220 to− 148 sequence, and the estrogen antagonist ICI182, 780 completely inhibited …
