MicroRNA-223 inhibits tissue factor expression in vascular endothelial cells

S Li, H Chen, J Ren, Q Geng, J Song, C Lee, C Cao… - Atherosclerosis, 2014 - Elsevier
Objective: Atherosclerosis is a chronic inflammatory process, in which vascular endothelial
cells (ECs) become dysfunctional owing to the effects of chemical substances, such as
inflammatory factor and growth factors. Tissue factor (TF) expression is induced by the
above chemical substances in activated ECs. TF initiates thrombosis on disrupted
atherosclerotic plaques which plays an essential role during the onset of acute coronary
syndromes (ACS). Increasing evidences suggest the important role of microRNAs as …