Murine model of Hirschsprung-associated enterocolitis II: surgical correction of aganglionosis does not eliminate enterocolitis
L Zhao, D Dhall, Z Cheng, HL Wang, TM Doherty… - Journal of pediatric …, 2010 - Elsevier
BACKGROUND: Hirschsprung disease (HD) results from aganglionosis of the colon, is
linked to acute and chronic enterocolitis (known as Hirschsprung-associated enterocolitis)
despite successful corrective surgery, and can lead to bacteremia and even death. The
genetic and molecular mechanisms underlying these disorders are largely unknown.
METHODS: We developed a microsurgical corrective pull-through procedure in mice, and
applied that to Ednrb−/− mice, which manifest aganglionic megacolon that is very similar to …
linked to acute and chronic enterocolitis (known as Hirschsprung-associated enterocolitis)
despite successful corrective surgery, and can lead to bacteremia and even death. The
genetic and molecular mechanisms underlying these disorders are largely unknown.
METHODS: We developed a microsurgical corrective pull-through procedure in mice, and
applied that to Ednrb−/− mice, which manifest aganglionic megacolon that is very similar to …
