Passive immune globulin therapy in the SIV/macaque model: early intervention can alter disease profile
NL Haigwood, A Watson, WF Sutton, J McClure… - Immunology …, 1996 - Elsevier
One of the major questions in AIDS is the role that the host immune system and the virus
play in the dynamics of infection and the development of AIDS in an infected individual. In
order to test the role of antibody in controlling viral infection, high-dose SIV-immune globulin
was passively transferred to infected macaques early in infection. Immune globulin purified
from the plasma of an SIV-infected long-term non-progressor macaque (SIVIG) or a pool of
normal immune globulin (normal Ig) was infused into SIVsmE660-infected macaques (170 …
play in the dynamics of infection and the development of AIDS in an infected individual. In
order to test the role of antibody in controlling viral infection, high-dose SIV-immune globulin
was passively transferred to infected macaques early in infection. Immune globulin purified
from the plasma of an SIV-infected long-term non-progressor macaque (SIVIG) or a pool of
normal immune globulin (normal Ig) was infused into SIVsmE660-infected macaques (170 …
