[HTML][HTML] Identification of the orphan G protein-coupled receptor GPR31 as a receptor for 12-(S)-hydroxyeicosatetraenoic acid
Y Guo, W Zhang, C Giroux, Y Cai, P Ekambaram… - Journal of Biological …, 2011 - ASBMB
Hydroxy fatty acids are critical lipid mediators involved in various pathophysiologic functions.
We cloned and identified GPR31, a plasma membrane orphan G protein-coupled receptor
that displays high affinity for the human 12-lipoxygenase-derived product 12-(S)-hydroxy-5,
8, 10, 14-eicosatetraenoic acid (HETE). Thus, GPR31 is named 12-(S)-HETE receptor (12-
HETER) in this study. The cloned 12-HETER demonstrated high affinity binding for 12-(S)-[3
H] HETE (K d= 4.8±0.12 nm). Also, 12-(S)-HETE efficiently and selectively stimulated GTPγS …
We cloned and identified GPR31, a plasma membrane orphan G protein-coupled receptor
that displays high affinity for the human 12-lipoxygenase-derived product 12-(S)-hydroxy-5,
8, 10, 14-eicosatetraenoic acid (HETE). Thus, GPR31 is named 12-(S)-HETE receptor (12-
HETER) in this study. The cloned 12-HETER demonstrated high affinity binding for 12-(S)-[3
H] HETE (K d= 4.8±0.12 nm). Also, 12-(S)-HETE efficiently and selectively stimulated GTPγS …