Mobilization of mitochondrial Ca2+ by hydroperoxy-eicosatetraenoic acid
C Richter, B Frei, PA Cerutti - Biochemical and biophysical research …, 1987 - Elsevier
C Richter, B Frei, PA Cerutti
Biochemical and biophysical research communications, 1987•ElsevierHydroperoxy-eicosatetraenoic acids (HPETEs) and less effectively, also hydroxy-
eicosatetraenoic acids (HETEs) stimulated Ca 2+ release from rat liver mitochondria. Ca 2+
release is accompanied by intramitochondrial pyridine nucleotide oxidation and hydrolysis.
Both Ca 2+ release and pyridine nucleotide oxidation are impeded when the flow of
electrons between pyridine nucleotides and HPETE is impaired. Measurements of the
mitochondrial membrane potential indicate that HPETE-stimulated Ca 2+ release is not due …
eicosatetraenoic acids (HETEs) stimulated Ca 2+ release from rat liver mitochondria. Ca 2+
release is accompanied by intramitochondrial pyridine nucleotide oxidation and hydrolysis.
Both Ca 2+ release and pyridine nucleotide oxidation are impeded when the flow of
electrons between pyridine nucleotides and HPETE is impaired. Measurements of the
mitochondrial membrane potential indicate that HPETE-stimulated Ca 2+ release is not due …
Abstract
Hydroperoxy-eicosatetraenoic acids (HPETEs) and less effectively, also hydroxy-eicosatetraenoic acids (HETEs) stimulated Ca2+ release from rat liver mitochondria. Ca2+ release is accompanied by intramitochondrial pyridine nucleotide oxidation and hydrolysis. Both Ca2+ release and pyridine nucleotide oxidation are impeded when the flow of electrons between pyridine nucleotides and HPETE is impaired. Measurements of the mitochondrial membrane potential indicate that HPETE-stimulated Ca2+ release is not due to uncoupling of mitochondria. It is suggested that HPETEs and HETEs may act as mobilizers of mitochondria. Ca2+ during signal transduction related to proliferation and tumor promotion.
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