Accumulation of duct cells with activated YAP parallels fibrosis progression in non-alcoholic fatty liver disease
MV Machado, GA Michelotti, TA Pereira, G Xie… - Journal of …, 2015 - Elsevier
Background & Aims Mechanisms that regulate regeneration of injured livers are complex.
YAP, a stem cell associated factor, controls liver growth in healthy adult mice. Increasing
nuclear localization of YAP triggers accumulation of reactive-appearing ductular cells (YAP+
RDC) with liver progenitor capabilities. The significance of YAP activation, and mechanisms
involved, are unknown in diseased livers. We evaluated the hypothesis that YAP is more
activated in injured livers that are scarring than in those that are regenerating effectively …
YAP, a stem cell associated factor, controls liver growth in healthy adult mice. Increasing
nuclear localization of YAP triggers accumulation of reactive-appearing ductular cells (YAP+
RDC) with liver progenitor capabilities. The significance of YAP activation, and mechanisms
involved, are unknown in diseased livers. We evaluated the hypothesis that YAP is more
activated in injured livers that are scarring than in those that are regenerating effectively …
