There is increasing interest in the role of ductular reaction as part of the pathogenesis and
characteristic histology of non-alcoholic steatohepatitis. However, earlier studies did not
separately assess the contribution of periportal and centrilobular zone ductular reaction over
the spectrum of non-alcoholic steatohepatitis, and their clinical significance remains unclear.
We herein analyzed the character of ductular reaction in each hepatic zone in non-alcoholic
steatohepatitis biopsies and for the first time evaluated the prognostic value of ductular …