[PDF][PDF] Secretion of Alzheimer's disease Aß amyloid peptide
GX Li, S Whyte, JE Tanner, G Eyin, K Beyreuther - Lab. Invest, 1998 - researchgate.net
Alzheimer's disease (AD) is characterized by the deposition of A3 (8A4) peptides of 39 to 43
amino acid residues, which are normal cellular metabolic products derived by proteolysis of
the amyloid precursor protein (APP). The physiologic function of A8/APP in vivo is poorly
understood. We analyzed human platelets for A8 production by immunoprecipitation
coupled to immunoblotting. A 4-kci A8 fragment that comigrates with an A340 synthetic
peptide and reacts with several antibodies specific for the N-and C-termini of A8 is detected …
amino acid residues, which are normal cellular metabolic products derived by proteolysis of
the amyloid precursor protein (APP). The physiologic function of A8/APP in vivo is poorly
understood. We analyzed human platelets for A8 production by immunoprecipitation
coupled to immunoblotting. A 4-kci A8 fragment that comigrates with an A340 synthetic
peptide and reacts with several antibodies specific for the N-and C-termini of A8 is detected …