Amyloid beta peptides in human plasma and tissues and their significance for Alzheimer's disease
AE Roher, CL Esh, TA Kokjohn, EM Castaño… - Alzheimer's & …, 2009 - Elsevier
BACKGROUND: We evaluated the amounts of amyloid beta (Aβ)) peptides in the central
nervous system (CNS) and in reservoirs outside the CNS and their potential impact on Aβ
plasma levels and Alzheimer's disease (AD) pathology. METHODS: Amyloid β levels were
measured in (1) the plasma of AD and nondemented (ND) controls in a longitudinal study,(2)
the plasma of a cohort of AD patients receiving a cholinesterase inhibitor, and (3) the
skeletal muscle, liver, aorta, platelets, leptomeningeal arteries, and in gray and white matter …
nervous system (CNS) and in reservoirs outside the CNS and their potential impact on Aβ
plasma levels and Alzheimer's disease (AD) pathology. METHODS: Amyloid β levels were
measured in (1) the plasma of AD and nondemented (ND) controls in a longitudinal study,(2)
the plasma of a cohort of AD patients receiving a cholinesterase inhibitor, and (3) the
skeletal muscle, liver, aorta, platelets, leptomeningeal arteries, and in gray and white matter …