Renal Vascular Reactivity in Mice: AngII-Induced Vasoconstriction in AT: 1A: Receptor Null Mice
X Ruan, MI Oliverio, TM Coffman… - Journal of the …, 1999 - journals.lww.com
The present study describes methodology and its application to evaluate renal reactivity in
acute studies on anesthetized mice. Renal blood flow (RBF) was measured using an
ultrasonic transit-time flowmeter and a non-cannulating V-shaped probe. An intrarenal artery
injection technique established feasibility and reproducibility of studies of renal vascular
reactivity to angiotensin II (AngII) in adult wild-type mice. The study also examined whether
AngII would affect RBF in mice lacking AT 1A receptors due to gene targeting. Mean arterial …
acute studies on anesthetized mice. Renal blood flow (RBF) was measured using an
ultrasonic transit-time flowmeter and a non-cannulating V-shaped probe. An intrarenal artery
injection technique established feasibility and reproducibility of studies of renal vascular
reactivity to angiotensin II (AngII) in adult wild-type mice. The study also examined whether
AngII would affect RBF in mice lacking AT 1A receptors due to gene targeting. Mean arterial …
