Loss of Klotho contributes to kidney injury by derepression of Wnt/β-catenin signaling
Aging is an independent risk factor for CKD, but the molecular mechanisms that link aging
and CKD are not well understood. The antiaging protein Klotho may be an endogenous
antagonist of Wnt/β-catenin signaling, which promotes fibrogenesis, suggesting that loss of
Klotho may contribute to CKD through increased Wnt/β-catenin activity. Here, normal adult
kidneys highly expressed Klotho in the tubular epithelium, but various models of
nephropathy exhibited markedly less expression of Klotho. Loss of Klotho was closely …
and CKD are not well understood. The antiaging protein Klotho may be an endogenous
antagonist of Wnt/β-catenin signaling, which promotes fibrogenesis, suggesting that loss of
Klotho may contribute to CKD through increased Wnt/β-catenin activity. Here, normal adult
kidneys highly expressed Klotho in the tubular epithelium, but various models of
nephropathy exhibited markedly less expression of Klotho. Loss of Klotho was closely …
