Multiple genes of the renin-angiotensin system are novel targets of Wnt/β-catenin signaling
Activation of the renin-angiotensin system (RAS) plays an essential role in the pathogenesis
of CKD and cardiovascular disease. However, current anti-RAS therapy only has limited
efficacy, partly because of compensatory upregulation of renin expression. Therefore, a
treatment strategy to simultaneously target multiple RAS genes is necessary to achieve
greater efficacy. By bioinformatics analyses, we discovered that the promoter regions of all
RAS genes contained putative T-cell factor (TCF)/lymphoid enhancer factor (LEF)-binding …
of CKD and cardiovascular disease. However, current anti-RAS therapy only has limited
efficacy, partly because of compensatory upregulation of renin expression. Therefore, a
treatment strategy to simultaneously target multiple RAS genes is necessary to achieve
greater efficacy. By bioinformatics analyses, we discovered that the promoter regions of all
RAS genes contained putative T-cell factor (TCF)/lymphoid enhancer factor (LEF)-binding …
