Involvement of human natural killer cells in asthma pathogenesis: natural killer 2 cells in type 2 cytokine predominance
H Wei, J Zhang, W Xiao, J Feng, R Sun… - Journal of allergy and …, 2005 - Elsevier
BACKGROUND: TH2 cells play a pivotal role in the pathogenesis of human asthma. Natural
killer (NK) cells are also thought to divide into NK1 and NK2 subsets. OBJECTIVE: Whether
NK1 or NK2 cells are involved in asthma remains unclear. METHODS: Triple-color flow
cytometry for detecting intracellular cytokine and NK cell surface phenotype from asthmatic
patients was used. The NK cell cloning and analysis with RT-PCR for cytokine expression
and Western blotting for signal transducer and activator of transcription activation were …
killer (NK) cells are also thought to divide into NK1 and NK2 subsets. OBJECTIVE: Whether
NK1 or NK2 cells are involved in asthma remains unclear. METHODS: Triple-color flow
cytometry for detecting intracellular cytokine and NK cell surface phenotype from asthmatic
patients was used. The NK cell cloning and analysis with RT-PCR for cytokine expression
and Western blotting for signal transducer and activator of transcription activation were …
