Independent, parallel pathways to CXCL10 induction in HCV-infected hepatocytes
J Brownell, J Wagoner, ES Lovelace, D Thirstrup… - Journal of …, 2013 - Elsevier
Background & Aims The pro-inflammatory chemokine CXCL10 is induced by HCV infection
in vitro and in vivo, and is associated with outcome of IFN (interferon)-based therapy. We
studied how hepatocyte sensing of early HCV infection via TLR3 (Toll-like receptor 3) and
RIG-I (retinoic acid inducible gene I) led to expression of CXCL10. Methods CXCL10, type I
IFN, and type III IFN mRNAs and proteins were measured in PHH (primary human
hepatocytes) and hepatocyte lines harboring functional or non-functional TLR3 and RIG-I …
in vitro and in vivo, and is associated with outcome of IFN (interferon)-based therapy. We
studied how hepatocyte sensing of early HCV infection via TLR3 (Toll-like receptor 3) and
RIG-I (retinoic acid inducible gene I) led to expression of CXCL10. Methods CXCL10, type I
IFN, and type III IFN mRNAs and proteins were measured in PHH (primary human
hepatocytes) and hepatocyte lines harboring functional or non-functional TLR3 and RIG-I …