Hepatitis B virus and hepatitis C virus interaction in Huh-7 cells
NS Eyre, RJ Phillips, S Bowden, E Yip, B Dewar… - Journal of …, 2009 - Elsevier
BACKGROUND/AIMS: Co-infection with hepatitis B virus (HBV) and hepatitis C virus (HCV)
increases the risk of development and the severity of chronic liver disease. Although
dominant and suppressive effects of each virus over the other have been reported in vivo, in
vitro studies of HBV/HCV co-infection have been limited to analysis of the effects of over-
expression of HCV proteins on HBV replication. METHODS: We have re-examined
HBV/HCV interactions in Huh-7 cells following co-infection with cell culture-propagated HCV …
increases the risk of development and the severity of chronic liver disease. Although
dominant and suppressive effects of each virus over the other have been reported in vivo, in
vitro studies of HBV/HCV co-infection have been limited to analysis of the effects of over-
expression of HCV proteins on HBV replication. METHODS: We have re-examined
HBV/HCV interactions in Huh-7 cells following co-infection with cell culture-propagated HCV …