Role of nicotinic receptors and acetylcholine in mucous cell metaplasia, hyperplasia, and airway mucus formation in vitro and in vivo
S Gundavarapu, JA Wilder, NC Mishra… - Journal of allergy and …, 2012 - Elsevier
BACKGROUND: Airway mucus hypersecretion is a key pathophysiologic feature in a
number of lung diseases. Cigarette smoke/nicotine and allergens are strong stimulators of
airway mucus; however, the mechanism of mucus modulation is unclear. OBJECTIVES: We
sought to characterize the pathway by which cigarette smoke/nicotine regulates airway
mucus and identify agents that decrease airway mucus. METHODS: IL-13 and γ-
aminobutyric acid type A receptors (GABAARs) are implicated in airway mucus. We …
number of lung diseases. Cigarette smoke/nicotine and allergens are strong stimulators of
airway mucus; however, the mechanism of mucus modulation is unclear. OBJECTIVES: We
sought to characterize the pathway by which cigarette smoke/nicotine regulates airway
mucus and identify agents that decrease airway mucus. METHODS: IL-13 and γ-
aminobutyric acid type A receptors (GABAARs) are implicated in airway mucus. We …