[HTML][HTML] Inhibitory potency and specificity of subtilase-like pro-protein convertase (SPC) prodomains
M Fugère, PC Limperis, V Beaulieu-Audy… - Journal of Biological …, 2002 - ASBMB
The SPCs (subtilisin-like pro-protein convertases) are a family of enzymes responsible for
the proteolytic processing of numerous precursor proteins of the constitutive and regulated
secretory pathways. SPCs are themselves synthesized as inactive zymogens. Activation of
SPCs occurs via the intramolecular autocatalytic removal of the prodomain. SPC
prodomains have been proposed as templates in the development of potent and specific
SPC inhibitors. In this study, we investigated the specificity and potency of complete …
the proteolytic processing of numerous precursor proteins of the constitutive and regulated
secretory pathways. SPCs are themselves synthesized as inactive zymogens. Activation of
SPCs occurs via the intramolecular autocatalytic removal of the prodomain. SPC
prodomains have been proposed as templates in the development of potent and specific
SPC inhibitors. In this study, we investigated the specificity and potency of complete …
