Activity-dependent volume transmission by transgene NPY attenuates glutamate release and LTP in the subiculum

AT Sørensen, I Kanter-Schlifke, EJD Lin… - Molecular and Cellular …, 2008 - Elsevier
Neuropeptide Y (NPY) gene transduction of the brain using viral vectors in epileptogenic
regions can effectively suppress seizures in animals, and is being considered as a
promising alternative treatment strategy for epilepsy. Therefore, it is fundamental to
understand the detailed mechanisms governing the release and action of transgene NPY in
neuronal circuitries. Using whole-cell recordings from subicular neurons, we show that in
animals transduced by recombinant adeno-associated viral (rAAV) vector carrying the NPY …