[HTML][HTML] Conservation of a glycine-rich region in the prion protein is required for uptake of prion infectivity

CF Harrison, VA Lawson, BM Coleman, YS Kim… - Journal of biological …, 2010 - ASBMB
Prion diseases are associated with the misfolding of the endogenously expressed prion
protein (designated PrP C) into an abnormal isoform (PrP Sc) that has infectious properties.
The hydrophobic domain of PrP C is highly conserved and contains a series of glycine
residues that show perfect conservation among all species, strongly suggesting it has
functional and evolutionary significance. These glycine residues appear to form repeats of
the GXXXG protein-protein interaction motif (two glycines separated by any three residues); …